REVERSIBLE INACTIVATION OF THYROTROPIC HORMONE BY ELEMENTAL IODINE
نویسندگان
چکیده
منابع مشابه
Reversible Inactivation of Thyrotropic Hormone by Elemental Iodine I. the Action of Iodine* by Alexander Albert,
The mechanism by which the thyrotropic or the thyroid-stimulating hormone (TSH) causes such marked growth and accelerated function of the thyroid remains a perplexing problem. Significant experiments in this direction have been reported by Rawson et al. (6, 8) who exposed TSH to slices of various organs in tissue culture. Of the various tissues studied, only thyroid, thymus, and lymph node were...
متن کاملPreparation of pituitary thyrotropic hormone.
The existence of a thyroid-stimulating hormone in anterior pituitary gland tissue has been known for 30 years (1, 2). During this time, considerable work has been done on the physiological and the pharmacological effects of the thyrotropic hormone administ’ered in the form of pituitary extracts which had been subjected t,o a varying degree of manipulation. Relatively little progress on the puri...
متن کاملPreparation of Pituitary Thyrotropic Hormone*
The existence of a thyroid-stimulating hormone in anterior pituitary gland tissue has been known for 30 years (1, 2). During this time, considerable work has been done on the physiological and the pharmacological effects of the thyrotropic hormone administ’ered in the form of pituitary extracts which had been subjected t,o a varying degree of manipulation. Relatively little progress on the puri...
متن کاملInactivation of Pepsin by Iodine
1. Pepsin solutions were iodinated at pH 5.0-6.0 until 10-20 per cent of the activity was lost and 1/20 (0.7 per cent) of the saturating amount of iodine had been introduced into the protein molecule. After alkaline hydrolysis 65 per cent of the original iodine was accounted for as mono-iodotyrosine although only 42 per cent was isolated as a crystalline product. No evidence was obtained to sup...
متن کاملThe Intracellular Localization of Pituitary Thyrotropic Hormone
The intracellular localization of a bovine anterior pituitary preparation of thyroid-stimulating hormone (TSH) was studied in guinea pigs and dogs. The preparation was administered intravascularly or applied directly to tissue sections. TSH was detected by an indirect technique utilizing bovine TSH antiserum and fluorescein-labeled anti-rabbit globulin; the presence of TSH in the tissue was ind...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1946
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)35202-x